![]() ![]() In individuals with chronic schizophrenia and in individuals with first episode psychosis we evaluated the combined effect of autistic traits and positive psychotic symptoms on psychosocial functioning. ![]() We tested this hypothesis in two clinical populations and one healthy population. A central prediction of this model is that functional impairment would be attenuated in individuals with mixed symptom expressions or genetic liability to both disorders. ![]() The diametric model, however, suggests that the disorders are etiologically and phenotypically diametrical, representing the extreme of a unidimensional continuum of cognition and behavior. The effect of such co-occurrence is hypothesized to worsen functional impairment. While diagnostically independent, they can co-occur in the same individual at both the trait and diagnostic levels. Functional impairment is a core feature of both autism and schizophrenia spectrum disorders. ![]()
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